Lily Clarke (21) a student from Halesmere, Surrey, UK is currently cited as the "Sleeping Princess". The nickname came because he was able to sleep until a full month. Even in his sleep that he missed some important life events such as birthdays and university exams. Lily suffering from Kleine-Levin syndrome that could make it able to sleep for a month to sleep. He only got up to eat and drink, and sleep again.For three years, Lily's parents had been "shopping" to various physicians, including seven different consultants visited. Lily also has a lot to undergo laboratory examinations and medical tests, but the doctors still can not find the type of disease is very rare. It is precisely his mother knew his mother's diagnosis with their children when reading in the Daily Mail, February 2010. "After I read the symptoms, I recognize my daughter's illness is Kleine-Levin Syndrome," said Lily's mother, Adele Clarke. "It's comforting to know someone knows the answer to my question.Kleine-Levin syndrome.Kleine-Levin syndrome (Kleine-Levin Syndrome abbreviated KLS) is a rare neurological disease in which sufferers can not control the sense of sleepiness. Sufferers can fall asleep for hours, days, weeks, even months, depending on how long the disease appears and relapse. Kleine-Levin syndrome was first named and reported scientifically by Willi Kleine and Max Levin in 1925. This syndrome was first discovered by French physician Pierre de Beauchène Edmé Chauvot in 1786.Patients can wake up only to eat or go to the bathroom. Patients can be awakened by someone else, but people always complain of feeling tired and fatigued. When patients wake up people acting like children because most of his memory erased memory when the patient asleep, the number of erased memories depends on how old the person is sleeping. And the patient is sensitive to sound and light when I wake. This disease recur without warning. Much research in the United States believe the cause of KLS disease is a mutation of genes or DNA carried by the parents of the patient. KLS but the exact cause is still unknown. While some researchers have speculated that there may be a tendency derivative or autoimmune disorders. Recent research also suggests that there may be related to dopamine deficiency due to the density of transporters in the striatum under the central nervous system in the brain.Research has been conducted on 108 patients with KLS found more frequently in the male sex than women with a ratio of 3:1. The average patient age was 15.7 years, with 81.7% experiencing their first episode between 10 and 20 years. Ages ranged from 6 to 59 years when patients experience their first episode. Patients women tend to be slightly older than men when the first onset, although they tend to experience puberty early. Racial factors were influential, KLS more often tigal frequency in Caucasians, and six times more frequently in the Jewish race.Symptoms experienced by patients when it was quiet and kept complaining her head felt strange and did not feel well. After that the patient continues to sleep, refused to leave his bed for 25 days. Every day almost nothing to eat and drink, sleep 23 hours a day. Time of one hour is used up only to eat and drink for a while then sleep again. Patients experiencing hypersensitivity or sensory stimuli is sensitive to noise and light. His face was like glass, without expression, stiff and irritable. He was talkative, expressive, emotional.At one time these patients have a relapse again back to sleep longer. He just woke up several hours a day and feel fear every time I wake up. Acting like a 4 year old child, hugging her teddy, sucking fingers, and crying, thinking he would die. Recurrent episodes of deep sleep. And even managed to go to university, their academic achievement below expectations. In the long sleep episodes, patients are stuck in a horror sometimes accompanied by frightening dreams. Sometimes, too, happens all things seem confusing. His brain can not process information. When asleep, the dream feels real. Conversely, when awake he was hallucinating and does not feel real.Patients often experience irritability, lethargy, and apathy. People with KLS patients often experience a sense of confusion and hallucinations. Symptoms of the cycle, can be experienced in a matter of weeks to months and even punctuated by symptom-free in a matter of weeks or even months to years. Hypersomnia is the main symptom of KLS, and is present in all subjects. During episodes of KLS, sufferers often spent 18 hours to sleep inside. Another symptom is mental changes during an attack. Patients difficult to wake up from sleep, and irritability or aggressive when prevented from sleeping. Patients also often show cognitive decline and may indicate confusion, amnesia, hallucinations, delusions, or have circumstances like a dream. About 75% of KLS patients had changes in eating behavior during the attack emerged, with the majority of these shows megaphagia or eat a lot. The report describes the patients who will eat anything placed in front of it without selecting eaten, so the tendency to consume excessive. Nearly half of KLS patients also experienced a kind of hypersexual behavior during the attack, disruption bergaulan, masturbation. Hypersexual behavior are more common in males than females.The diagnosis of KLS is very difficult because there are no typical symptoms to be sure. KLS is not a diagnosis of exclusion, in which a doctor must first eliminate a long list of other conditions whose symptoms are almost identical. Because hypersomnia is the main symptom, many patients are initially treated for sleep disorders. KLS Patients initially dievaluai metabolic problems including diabetes and hypothyroidism. Several other disorders are also similar symptoms of KLS, by doing MRIuntuk see abnormalities of brain lesions, tumors, or inflammation. Multiple sclerosis disease also has a neurological disorder that can be similar to the symptoms to KLS.KLS sufferers often mistakenly diagnosed with psychiatric disorders. The period of drowsiness, hyperphagia, and withdrawal from the environment similar to major depression disorder. Some people experience brief periods of high energy after this episode that looks like a manic episode, so some patients who are not properly diagnosed with bipolar disorder. There are a number of symptoms or disorder that is similar perceptions of primary psychiatric disorders. Disorders Narcolepsy and Klüver-Bucy syndrome may also experience similar symptoms. Before the final diagnosis can be made, all other possibilities should be careful to be removed.The disease is incurable, but there are a number of therapies that can improve patient quality of life. There is no definitive treatment for Kleine-Levin syndrome. Timulan drug therapy, such as amphetamines, methylphenidate, and modafinil, administered orally, can be used to treat sleepiness, but unfortunately did not improve cognition or mental state changes. There are some similarities between Kleine-Levin syndrome and bipolar disorder, thus giving lithium and carbamazepine was reported beneficial in some cases in prevention. This disorder must be differentiated from the cycle of sleep disruption during the premenstrual period in which adolescent girls can be controlled with hormonal contraceptives.
